ABSTRACT
Abstract The reconstruction of facial surgical defects is usually challenging for the dermatologic surgeon. Three different cases of facial defects in which tunneled island flaps were used are reported. In 2 cases, wide defects involving the nasal dorsum and ala were repaired using a nasolabial island flap tunneled through the lateral side of the nose. A tunneled island glabellar flap was used for medial canthus reconstruction in the third case. Despite complex pedicle dissection and frequent trapdoor deformation, tunneled island flaps allow reconstruction of wide defects in a single-staged procedure, camouflaging the scar of the donor area in boundaries of cosmetic units and preserving the facial central symmetry.
Subject(s)
Humans , Male , Female , Surgical Flaps/surgery , Facial Neoplasms/surgery , Carcinoma, Squamous Cell/surgery , Nose Neoplasms/surgery , Skin Transplantation/methods , Carcinoma, Basal Cell/surgery , Treatment Outcome , Subcutaneous Tissue/transplantationABSTRACT
Abstract Dyspigmentation along the Blaschko lines is strongly suggestive of a mosaic skin disorder. We report a 9-year-old male patient who presented with swirls and streaks of both hypo and hyperpigmentation involving the entire body. Additionally, he had hypertrichosis, musculoskeletal and minor neurodevelopment abnormalities but no intellectual disability. Cultured fibroblast displayed trisomy 7 mosaicism, which can explain this pigmentary phenotype. Widespread dyspigmentation associated with involvement of other organs should prompt systemic examination to detect additional anomalies and genetic evaluation should be considered, even with normal fetal karyotype.
Subject(s)
Humans , Male , Child , Skin Abnormalities/pathology , Trisomy/pathology , Hypopigmentation/genetics , Hypopigmentation/pathology , Hyperpigmentation/genetics , Hyperpigmentation/pathology , Syndrome , Chromosomes, Human, Pair 7 , Hypertrichosis/genetics , Hypertrichosis/pathology , MosaicismABSTRACT
Abstract: Non-steroidal, anti-inflammatory drugs, followed by antibiotics, are the main causes of fixed drug eruption. They provoke one or several round erythematous or bullous lesions that recur in the same place after taking the causative medication. A positive patch test on residual, lesional skin can replace satisfactorily oral reintroduction. We describe the case of a 74-year-old woman with numerous, rounded, erythematous lesions on the trunk and recurrent blistering on the fifth right-hand finger, which developed a few hours after taking etoricoxib. Lesional patch testing with etoricoxib was positive and reproduced the typical pattern of a fixed drug eruption upon histopathology. We emphasize the specific reactivity of the etoricoxib patch test, and the capacity to reproduce the histologic pattern of the reaction.
Subject(s)
Humans , Female , Aged , Pyridines/adverse effects , Sulfones/adverse effects , Patch Tests/methods , Drug Eruptions/etiology , Cyclooxygenase 2 Inhibitors/adverse effects , Drug Eruptions/pathologyABSTRACT
Multiple minute digitate hyperkeratosis is a rare, non-follicular dermatosis, with fewer than 30 cases described worldwide. It can be either acquired or inherited in an autosomal dominant pattern. We describe the case of an 83-year old patient with life-long, multiple, digitate, milimetric lesions, and a positive family history for the same dermatosis.
.